|
KMID : 0377220010260020027
|
|
Medical Journal of Chosun Univercity
2001 Volume.26 No. 2 p.27 ~ p.35
|
|
|
Reclassification and Significance of Expression of Bcl-2, Cyclin D1, Bcl-6 and p53 Protein in Primary Gastrointestinal B Cell Lymphoma
|
|
Seo Jeong-Gjyn
Kim Tae-Won
Kim Byung-Soo
Cho Eun-Taeg
Park Chan-Kuk
Kim Man-Woo
|
|
|
Abstract
|
|
|
Background and Objectives : In recent years, the REAL (Revised European American Lymphoma) classification provided a new category of MALT (mucosa-associated lymphoid tissue) lymphoma and mantle cell lymphoma in B cell lymphomas. We have analyzed the expression of bcl-2, cyclin D1, bcl-6 and p53 and correlated with the subtypes and histologic grade of primary gastrointestinal B cell lymphoma. Also we investigated the usefulness of immunophenotypic features in diagnosis of low grade B cell lymphoma.
Materials and Methods : Twenty-two cases of primary gastrointestinal B cell lymphoma were recategorized in low grade MALT lymphoma, low/high grade MALT lymphoma, high grade MALT lymphoma, and diffuse large cell lymphoma according to the morphological findings. We investigated the expression of bcl-2, cyclin D1, bcl-6 and p53 by immunohistochemical method.
Results : The bcl-2 protein expression was higher in the low grade MALT lymphoma than in the high grade lymphoma. The cyclin D1 protein expression was negative in all cases. The expression of bcl-6 and p53 protein was negative in all low grade MALT lymphoma.
Conclusion : The results suggest that we can differentiate the low grade lymphoma from the high grade lymphoma by immunohistochemical staining for bcl-2, bcl-6, and p53 protien.
|
|
|
KEYWORD
|
|
|
Gastrointestinal lymphoma, Bcl-2, Cyclin D1, Bcl-6, p53
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|